Diabetic nephropathy is a complication of diabetes mellitus that leads to end-stage renal disease (ESRD) of the kidneys. When nephropathy is present in patients with diabetes, the disease is typically chronic and progressive. Current treatments that include controlling blood sugar, hypertension, and blood lipids do not stop the relentless progression to ESRD, eventually requiring kidney transplantation or chronic dialysis. Effective drug treatment of diabetic nephropathy is a high unmet medical need due to the limited usefulness of available drugs and the global diabetes epidemic.
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