Scientific Advisory Board
Ampio’s Scientific Advisory Board is comprised of world-renowned experts in their fields, each with over three decades experience in pioneering innovations in medicine and basic research.
Dr. Brody earned his MD (1964) and PhD in Biochemistry (1965) from the University of Chicago and accepted a Postdoctoral Fellow position at the Department of Biophysics, Laboratory of E.P. Geiduschek in Chicago. He then went to Geneva, Switzerland (1965-1968) and continued his research as a Postdoctoral Fellow, Department of Molecular Biology. Dr. Brody moved from Geneva to the Biochemistry Department of the Institut de Biologie Physico-Chimique, Paris, France and joined the French National Research Council (C.N.R.S.) in 1971 as “Chargé de Recherche” and was promoted to the position of “Maître de Recherche” in 1973. In 1983, Dr. Brody took a sabbatical to the California Institute of Technology in Pasadena, working in John Abelson’s laboratory studying the splicing of pre-mRNA in S. cerevisiae and was able to label, isolate, and prove the structure of an in vivo generated lariat intron RNA and then found that in vitro splicing takes place specifically on a 40S particle which he named the spliceosome. Their article in Science (228, 963-7, ) was one of the 100 most cited life science articles for the year 1985.
Returning to France in August, 1985, Dr. Brody worked on mammalian pre-mRNA splicing, and in particular on tissue specific splicing, skeletal muscle-specific splicing of b-tropomyosin pre-mRNA and in 1988, moved to Gif-sur-Yvette, where splicing was the major pursuit of the laboratory. In 1992, Dr. Brody was recruited to become Professor, Chairman of the Department of Biology, Department of Biological Sciences SUNY Buffalo, USA.
Dr. Brody is the author of a large number of research papers in the field of molecular biology and proteomics.
Milestones accomplished by Dr. Rubinstein and his team in the development of this new field of medicine include providing the first unrelated stem cell transplant for hematopoietic reconstitution, receiving the first IND from the FDA that allowed cord blood processing and freezing for transplantation to proceed (1996) and, in November 2011, the first Biologics License issued by the FDA for any stem cell preparation.
Dr. Rubinstein earned his medical degree from the Universidad de Chile in 1962 and completed a surgical residency at Hospital Clinico of the Universidad de Chile, followed by a fellowship at the M.I. Bassett Hospital, Columbia University. He also completed a National Institutes of Health (NIH) International Postdoctoral Research fellowship at Mount Sinai Hospital in New York City. His study of immunogenetics, which encompasses the structure and function of genes that regulate immune responses, control the acceptance or rejection of tissue and organ transplants, and affect susceptibility to certain types of diseases, led to his appointment as an investigator at the Lindsley F. Kimball Research Institute at the New York Blood Center (NYBC) and eventually as Director of the Fred H. Allen Jr. Laboratory of Immunogenetics. He served as Clinical Professor in the Pathology Department at Columbia University School of Medicine.
He has also conducted collaborative research on the Genetics of Juvenile (Type I) Diabetes Mellitus in humans and showed that the disease is inherited as a recessive gene with incomplete penetrance through genes in the HLA region. He has also conducted studies on the genetic structure of the HLA region in humans and its homologs in other species and shown the genetic linkage of several components of the complement system including Factor B in the alternative pathway and C2 and C4, active in the classical pathway.
He has also worked in the genetics of human blood groups and discovered the existence of Fy6, an allele of the Duffy blood group system that serves as the receptor for the binding of P. vivax malaria merozoites.
Dr. Rubinstein is the author of more than 260 research papers on immunogenetics, cord blood banking and hematopoietic stem cell transplantation.