Scientific Advisory Board

Ampio’s Scientific Advisory Board is comprised of world-renowned experts in their fields, each with over three decades experience in pioneering innovations in medicine and basic research.

Edward N. Brody, MD, PhD, a physician, molecular biologist, biochemist and biophysicist by training, is the Chief Medical Officer Emeritus of SomaLogic Inc. and Adjunct Professor, Department of Molecular, Cellular and Developmental Biology at the University of Colorado, Boulder. Dr. Brody served as Vice President, Drug Discovery, NeXstar Pharmaceuticals, Boulder, Colorado from 1998 to 1999 and has been working in proteomics at SomaLogic since its inception in 2000. Proteomics is a branch of biotechnology concerned with applying the techniques of molecular biology, biochemistry, and genetics to analyzing the structure, function, and interactions of the proteins produced by the genes of a particular cell, tissue, or organism, with organizing the information in databases, and with applications of the data. The company has developed protein-binding reagents and technologies that can efficiently, accurately and rapidly identify and quantify 5,000 proteins across approximately eight logs of concentration in small sample volumes that support advanced biomarker discovery, diagnostics development, and pharmaceutical discovery and development.

Dr. Brody earned his MD (1964) and PhD in Biochemistry (1965) from the University of Chicago and accepted a Postdoctoral Fellow position at the Department of Biophysics, Laboratory of E.P. Geiduschek in Chicago. He then went to Geneva, Switzerland (1965-1968) and continued his research as a Postdoctoral Fellow, Department of Molecular Biology. Dr. Brody moved from Geneva to the Biochemistry Department of the Institut de Biologie Physico-Chimique, Paris, France and joined the French National Research Council (C.N.R.S.) in 1971 as “Chargé de Recherche” and was promoted to the position of “Maître de Recherche” in 1973. In 1983, Dr. Brody took a sabbatical to the California Institute of Technology in Pasadena, working in John Abelson’s laboratory studying the splicing of pre-mRNA in S. cerevisiae and was able to label, isolate, and prove the structure of an in vivo generated lariat intron RNA and then found that in vitro splicing takes place specifically on a 40S particle which he named the spliceosome. Their article in Science (228, 963-7, [1986]) was one of the 100 most cited life science articles for the year 1985.

Returning to France in August, 1985, Dr. Brody worked on mammalian pre-mRNA splicing, and in particular on tissue specific splicing, skeletal muscle-specific splicing of b-tropomyosin pre-mRNA and in 1988, moved to Gif-sur-Yvette, where splicing was the major pursuit of the laboratory. In 1992, Dr. Brody was recruited to become Professor, Chairman of the Department of Biology, Department of Biological Sciences SUNY Buffalo, USA.

Dr. Brody is the author of a large number of research papers in the field of molecular biology and proteomics.


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